Vaccine scientists have been chasing variants. Now, they’re seeking a universal coronavirus vaccine.

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Tue, 2022-02-15 12:13 — mike kraft

Vaccine scientists have been chasing variants. Now, they’re seeking a universal coronavirus vaccine. To many scientists, developing variant-specific vaccines is a short-term, shortsighted and unsustainable strategy. Carolyn Y. Johnson Washington Post

Volunteers are rolling up their sleeves to receive shots of experimental vaccines tailored to beat the omicron variant — just as the winter coronavirus surge begins to relent.

By the time scientists know whether those rebooted vaccines are effective and safe, omicron is expected to be in the rearview mirror. Already, mask mandates are easing. People are beginning to talk about normalcy.

FAQ: What to know about the omicron variant of the coronavirus

The disconnect highlights the exhausting scientific chase of the last year — and the one that lies ahead. And it underscores a more pressing, overarching conundrum: Is chasing the latest variant a viable strategy? Instead of testing and potentially deploying a new shot when a new variant pops up, what if a single vaccine could thwart all iterations of this coronavirus and the next ones, too?

By now, rebooting vaccines to match a new variant is becoming part of scientific muscle memory. Drug companies made vaccines to fight beta, delta and now omicron. None of those shots have been needed yet, but to many scientists, it is a short-term, shortsighted and unsustainable strategy.

“You don’t want to play this whack-a-mole approach,” said David R. Martinez, a viral immunologist at the University of North Carolina at Chapel Hill. “This could go on forever.”

The original shot has held up remarkably well, but there’s no guarantee how it will fare against the next variant. Scientists like Martinez want to end the cycle of catch-up.

They are inventing vaccines designed to foster broad protection — an immunity wall that will repel not only the variants of SARS-CoV-2 that we know about, but those yet to emerge.

At minimum, the world needs a truly variant-proof vaccine. Even better would be a shot that would also stop a future pandemic, protecting against a yet-unknown coronavirus that will jump from animals into people in the years to come.

Some experts have questioned why there isn’t already an Operation Warp Speed for these universal vaccines.

Anthony S. Fauci, President Biden’s chief medical adviser, stresses the need for patience, along with urgency. There are scientific gaps needing to be filled to build a vaccine that is broadly protective and lasts a long time — and the National Institutes of Health last fall awarded $36 million to groups trying to answer basic questions.

“You shouldn’t confuse the rapidity and the ease with which we developed a coronavirus vaccine for SARS-CoV-2 with the extraordinary obstacles you might face in trying to get a vaccine that protects” more broadly, Fauci said in an interview with The Washington Post. “There’s a lot of scientific discovery that needs to go into that.”

Privately, though, scientists say Fauci is urging them to hurry up. ...

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