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Drug-resistant "dual mutant" flu strains, first detected in Hong Kong, now being tracked in U.S.

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At least two human cases of the new so-called "dual mutant" strains of H1N1 influenza have been detected in U.S. patients, the Centers for Disease Control and Prevention said Wednesday, with genetic changes that could cut the effectiveness of the main flu antiviral that hospitals rely on.

An analysis of the new H1N1 flu viruses with these two concerning mutations – which scientists call I223V and S247N, describing changes to key surface proteins of the virus – was published this week in the agency's Emerging Infectious Diseases journal.

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“There’s active global surveillance going on looking for these mutations,” said Dr. Andy Pekosz, a virologist at the Johns Hopkins Bloomberg School of Public Health. “We want to know when they come up, because that could really have major implications for how we treat influenza.”

For now, though, experts say the threat is low.

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